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KMID : 0351619640050010243
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Kyungpook Medical Journal
1964 Volume.5 No. 1 p.243 ~ p.248
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Excretion of 5-HIAA in Urine of Rabbits in Relation to Reserpin Reversal by Stimulant
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Abstract
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Reserpin and Nialamidc were administered to the rabbits separately or in combination, and the changes of motor activity, body te.-nperature and the ptosis were observed for 4S hours fallowing the administration. The variations of the excretion of 5HIAA were determined in amount by the Nitroso-naphthol rr_e"hed at the same time.
Following results were obtained:
(1) In reserpin administered group the hypoa.ctivity, the decrease in body temperature, and the ptosis were noticed within an hour after the administration and tended to continue up to 2432 hours, recovering in 43 hours. The excretion of ~HIAA increased since 3 hours after the administration and remain the tendency of incrsase until 1824 hcurs showing recovery to the normal value within 48 hcurs.
(2) In nialamide administered group only the hyperactivity was noticed. no significant changes in the excretion of 5HIAA were observed.
(3) In reserpin pretreated and nialamide administered group the course of the changes of mctor activity and the ptosis were similar to that of reserpin administered group. The varia tion of the excretion of 5HIAA in urine showed the same tendency as that in reserpin administered group.
(4) In nialamide pretreated and reserpin administered group, the hypcactivity, the decrease in body temperature, and the ptosis were not observed. The excretion of 5HIAA also showed no significant change.
In interpreting abave results the author comes to the assumption that the reserpin reversal by monoamirn oxidase inhibitor is closely related to the variation of excretion of 5HIAA in urine which represents the pharmacodynamic metabolism of serotonin in the brain. The implication that the three kinds of pharmacological phenomenon namely the hypoactivity, the decrease in body temperature and the ptosis v~rhich are produced by reserpin could be one of the effective screening rr_ethcds of stimulant drugs in the sense of re:~erpin reversal, is discussed.
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